Research on Perfusion Imaging Parameters,Normal Perfusion Performance and the Influencing Factors of 64-Slice Spiral CT Kidney Perfusion Imaging

【Objective】To explore all the cortex and medulla perfusion parameters of the normal kidney and to analyze the correlation between these perfusion parameters and age,sex and right or left side.【Methods】Twenty eight healthy volunteers were studied in this group with SIEMENS Sensation 64-slice spiral CT.Perfusion scans were performed at the location of the renal hilus with 50mL nonionic contrast administration(300mg/mL) at the speed of 6mL/s.Data postprocessing was performed on SIEMENS workstation by using kidney analyzing software in the package of body perfusion.All the cortex and medulla perfusion parameters of the normal kidney were measured.The perfusion parameters were then compared by using the paired t-test and two-sample t-test to determine whether there were significant differences between right and left sides,male and female.And the correlation between age and perfusion parameters was analyzed.【Results】①The time-density curves of 28 bilateral normal renal cortex and medulla were symmetric and even coincident.The mean BF,BV,TTP,PS and PBV of renal cortex were 301.56±68.79mL/(100 mL·min),38.86±5.83 mL/100 mL,11.17±1.12s,42.85±10.88mL/(100 mL·min) and 67.53±10.25 mL/100 mL,respectively.And the mean BF,BV,TTP,PM and PBV of renal medulla were 157.78±34.58 mL/(100 mL·min),28.53±3.90 mL/100 mL,12.38±1.15s,75.59±22.68 mL/(100 mL·min) and 28.24±0.94 mL/100 mL,respectively.②Using analysis of variance,there were no gender and right or left side differences in the perfusion parameters(The P value of the BF,BV,TTP,PS and PBV of renal cortex wese 0.55,0.73,0.60,0.16,0.68;The P value of the BF,BV,TTP,PS and PBV were 0.09,0.72,0.60,0.09,0.65.P0.05),but the perfusion parameters of cortex and medulla was lower in the elders(P0.05). 【Conclusion】①64-slice spiral CT perfusion imaging can measure the cortex and medulla perfusion parameters of the normal kidney and quantitatively evaluate the haemodynamic changes in normal renal tissue.②There are no gender and right or left side differences in all the perfusion parameters of the normal kidney,but there is relationship between age and all the perfusion parameters.