Study on the Clinical Value of Serum Homocysteine and Uric Acid levels in the Coronary Heart Disease

Objective: To investigate the clinical value of serum homocysteine and uric acid levels in the coronary heart disease(CHD). Methods: 182 patients with CHD diagnosed by coronary angioplasty were enrolled, including 78 SAP patients,m56 UAP patients and 48 AMI patients, while 60 patients with simple essential hypertension(EH) were selected as controls. The levels of serum Hcy and UA in all patients were determined, then their correlation with different groups were analyzed. Results:(1)The serum Hcy and UA concentrations in CHD group were both higher than those in EH group(P0.05).(2)Serum Hcy and UA concentration in AMI group were higher than those in SAP and UAP groups(P0.05).(3)Spearman correlation analysis indicated serum Hcy and UA werer highly positive correlated in AMI group(P0.01).(4)Logistic regression analysis indicated the increase of serum Hcy and UA levels were the risk factors in CHD, while the increase of serum Hcy was single risk factor in AMI patients. Conclusion: Hyperhomocysteinemia and Hyperuricemia were important risk factors in CHD, the detection of both serum Hcy and UA were of great importance in the prevention of CHD.