Effects of different doses of atorvastatin on the blood lipids of patients treated with coronary intervention

Objective To investigate the effects of different doses of atorvastatin on the blood lipids and cardiac ischemic events of patients with coronary heart disease treated with percutaneous coronary intervention(PCI).Methods 90 cases of coronary heart disease patients with successful PCI,were randomly divided into three groups: combining conventional therapy with atorvastatin 20mg/d,40mg/d and 80mg/d respectively.the blood lipids,cardiac ischemic events and adverse reaction in the three groups of patients were observed after 3 months treatment of atorvastatin.Results The lipid-lowering effect of atorvastatin was good and it was more obvious with increasing the dose of atorvastatin(P0.05 and P0.01).Compared with 20mg/d group,the rates of cardiac ischemia event decreased significantly in 40mg/d group and 80mg/d group(P0.05).There were no significant differences in incidence of adverse events in three groups(P0.05).Conclusions The application of atorvastatin in patients with coronary heart disease after PIC can reduce blood lipids significantly and prevent restenosis after PCI.The efficacy increased with increasing the doses of atorvastatin but no serious adverse events.It is worthy of clinical application.