Influence of different doses of atorvastatin on the blood lipids and cardiac ischemic events after percutaneous coronary intervention in patients with coronary heart disease

Objective To observe the influence of different doses of atorvastatin on the hyperlipidemia and cardiac ischemic events after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD).Methods 132 cases with CHD in our hospital were randomly divided into group A,group B and group C,and they were given different doses of atorvastatin after the PCI surgery,.The changes of lipid levels and cardiac ischemic events were compared.Results TC,TG and LDL-C levels in the three groups were significantly decreased after treatment,and the HDL-C level significantly increased (P ＜ 0.05),TC and LDL-C of group B and group C were significantly lower(P ＜ 0.05).The cardiac ischemic events and the incidence rate of a variety of adverse reactions of group C were less than group A and group B,but the differences were not significant (P ＞ 0.05).Conclusion Highdose atorvastatin (40mg) can effectively decrease blood lipid levels in CHD patients after PCI,reduce the incidence rate of cardiac ischemic events,and it is safe,effective,which is worth to be promoted and applicated in clinical. Key words: Atorvastatin;  Percutaneous coronary intervention;  Blood lipids;  Cardiac ischemic events