Clincal Observation of Naokang Granula for Treatment of Post-stroke Mild Cognitive Impairment

Objective To observe the therapeutic effect of Naokang Granula,a Chinese herbal patent with the actions of tonifying liver and kidney,activating blood and removing stasis,resolving phlegm and inducing resuscitation for the treatment of post-stroke mild cognitive impairment with insufficiency of marrow-reservoir.Methods Randomized controlled trial was adopted,and 60 patients with post-stroke cognitive impairment were equally divided into treatment group and control group.The control group received oral administration of Nimodipine tablets while the treatment group was treated with Naokang Granula.Both groups were treated for 6 weeks.A comparison of therapeutic effect was made in both groups before and after treatment by mini-mental state examination(MMSE) and Montreal cognitive assessment scale(MoCA).Results After treatment,the treatment group had a total effective rate of 66.67%,and the control group had a total effective rate of 53.33%.The effective rate in the two groups had no significant difference(P0.05).The scores of MMSE and MoCA were improved in both groups after treatment(P0.01 compared with those before treatment),and the improvement of MoCA in the treatment group was superior to that in the control group(P0.01).Conclusion Naokang Granula is effective on improving cognitive function in patients with post-stroke mild vascular cognitive impairment with insufficiency of marrow-reservoir.