2011•Journal of clinical and experimental medicineRequires access
Clinical significance of detection of serum Cystatin C in early stage of diabetic nephropathy
Cai Wen-hu
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Abstract
Objective To study the clinical significance of detecting serum level of Cystatin C in early diagnosis of diabetic nephropathy in patients with type II diabetes,and to find out ideal markers for glomerular filtration rate.Methods According to the idea of Chung,urinary albumin excretion rate is important in classification,92 patients with typeⅡdiabetes are divided into 3 groups: clinical proteinuria group(group A),microalbuminuria group(group B) and negative albuminuria group(group C).Thirty healthy persons are selected as control group.Serum level of Cys-C is detected by latex particle enhanced immunoturbidimetric assay,and serum levels of Scr and Ucr are detected by enzymic method,and serum level of BUN is detected by urease-berthelot method.Their creatinine clearance rates(Ccr) are calculated and analyzed.Results Serum level of Cys C in diabetic nephropathy group is significantly higher than that of control group(P0.05).Serum levels of Cys C,Scr and BUN and Ccr in patients of group A are higher than those of patients in groups B and C(P0.05).Conclusion The detection rate of serum Cys C is high in early stage of diabetic nephropathy.Serum level of Cys C is an ideal serological marker for detecting early renal impairment in patients with diabetes.