2004•Europe PMC (PubMed Central)Requires access
The protective effect of tannic acid supplementation on oxidative injury induced by #gamma#-irradiation in mice
Xu-Jun Qin, Hai Chun-xu, Wei He, Xin Liang, Hongli Chen, Rui Liu
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Abstract
Objective: To study the protective effect of tannic acid supplementation on oxidative injury induced by γ-irradiation in mice. Methods: Fifty mice were randomly divided into five groups: control group, irradiated group and three tannic acid supplementation groups, which were supplied with different dosages of tannic acid by gavage daily. 2 d later, except for the control group, other mice were irradiated by 60Co. 2 d after irradiation, all animals were killed and the peripheral blood picture and the content of malondialdehyde (MDA), and the activities of superoxide dismutase (SOD) were examined. Results: In irradiated group, the peripheral blood WBC, RBC, PLT, Hb and HCT decreased significantly. MDA contents and SOD activity in serum and liver tissue of irradiated group increased and decreased respectively as compared with the control. These changes were in dose dependent manner.Tannic acid supplementation might prevent such changes. Conclusion: Tannic acid has effective protection on oxidative injury induced by irradiation in mice.