The Clinical Significance of Serum Cystatin C in Early Renal Dysfunction of Patients with Gestational Diabetes Mellitus

Objective: To evaluate the clinical significance of the serum cystatin C( Cys-C) in early renal dysfunction of patients with gestional diabetes mellitus( GDM). Methods: Serum concentrations of Cys-C, creatinine( Scr) and Uric acid( UA) were measured in 64 patients with gestional diabetes mellitus( GDM group) and 128 normal pregnant women( control group). The 24-hour urinary protein quantification and HbA1c levels were also detected in the GDM group. According to HbA1c level,32 cases with HbA1c≥6. 5% were assigned into group 1,and 32 cases with HbA1c 6. 5% into group. Results: Serum Cys-C level in group 1 was significantly higher than those in group 2 and control group( P0. 05),and that in group 2 was significantly higher than that in control group( P0. 05). Serum UA and Scr levels in group 1 were both significantly higher than those in group 2 and control group( P0. 05). Serum UA and Scr levels in group 2 and control group had no significant difference( P0. 05). Correlation analysis showed that significant positive correlations could be found between serum Cys-C level and 24-hour urinary protein quantification and HbA1c in GDM patients( r =0. 814,r =0. 947,P0. 01). Conclusions: Serum Cys-C may work as a potential predictive marker to the early renal function in patients with gestional diabetes mellitus.