2007•Journal of Medical ForumRequires access
Effects of Sodium Nitroprusside,Dopaine in Treatment of Chronic Congestive Heart Failure
Manhua Chen
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Abstract
Objective To detect effect and safety of combination of sodium nitroprusside,dopamine in treatment of chronic heart failure(CHF),and the effect on level of plasma Nt-proBNP.Methods 105 patients with heart failure were divided into treatment group and control group randomly.The control group was treated with diuretic and aminophylline.And treatment group was treated with sodium nitroprusside,dopaine additionally.The treatment last 10days.Comparison was done between two groups,as the evaluation of improvement of heart function,improvement of signs of heart failure,the change of left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVDd)by ultrasonography of heart as evaluation index,and the level of plasma Nt-proBNP was measured before and after treatment in each group.Results The total effective rate(94.5%),total responsive rate(60.2%),LVEF in treatment group were significantly higher than those in control group after treatment(P0.05).And the plasma Nt-proBNP level was significantly lower than that in control group(P0.05).Conclusion Effects of combination of sodium nitroprusside,dopaine in treatment of low blood pressure with CHF were significant.Plasma Nt-proBNP level has considerably high sensibility in the evaluation of treatment effect of heart failure.