Clinical evaluation of H-FABP in diagnosis of AMI

Objective To investigate the application value of heart-type fatty acid binding protein(H-FABP) in the diagnosis of acute myocardial infarction(AMI).Methods 95 chest pain patients with suspicious AMI were selected.Serum H-FABP at 0-3,3-6,6 h after onset was detected by the rapid panel test method and compared with the detection results of cTnI and serum CK-MB.The sensitivity and specificity in diagnosis of different onset time periods of AMI were analyzed among H-FABP,cTnI and CK-MB.Results The detection rate of 3 indicators in all chest pain patients had no statistical difference(P0.05).The positive rate of H-FABP in the AMI group was 72.9%,significantly higher than 66.7% of cTnI and 62.5% of CK-MB with statistical difference(P0.05).The sensitivities of H-FABP for diagnosing AMI 0-3 h(70.00%),3-6 h(82.61%) periods were significantly higher than cTnT(20.00% and 65.22%) and CK MB(10.00% and 65.22%).In the specificity,H-FABP was higher than CK-MB and lower than cTnI.Conclusion H-FABP has the high sensitivity and better specificity in diagnosis of early AMI,which may be suitable for the diagnosis of AMI in the early phase.