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2013•Chinese Journal of Spectroscopy LaboratoryRequires access

Determination of 5-Aminosalicylic Acid in Different Releasing Medium by Ultraviolet Spectrophotometry

Huang Yuan

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Abstract

The contents of 5-aminosalicylic acid(5-ASA) in 0.1mol ? L~(-1) HCl,PBS6.8,0.5% pectin enzyme solution were determined by UV spectrophotometry with detection wavelengths of 303,330,298nm respectively.There was a good linear relationship between drug concentration of 5-ASA and adsorption A in the range of 10—40μg ? mL~(-1) with correlation coefficients of 0.9999, 0.9999,0.9997,respectively,and recoveries of different medium were greater than 98%with RSD less than 1%.The method has simple operation,accurate resultsand,can be applied to determination of content of 5-ASA preparation.

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What this paper is about

The contents of 5-aminosalicylic acid(5-ASA) in 0.1mol ? L~(-1) HCl,PBS6.8,0.5% pectin enzyme solution were determined by UV spectrophotometry with detection wavelengths of 303,330,298nm respectively.There was a good linear relationship between drug concentration of 5-ASA and adsorption A in the range of 10—40μg ? mL~(-1) with correlation coefficients of 0.9999, 0.9999,0.9997,respectively,and recoveries of different medium were greater than 98%with RSD less than 1%.The method has simple operation,accurate resultsand,can be applied to determination of content of 5-ASA preparation.

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Available abstract

The contents of 5-aminosalicylic acid(5-ASA) in 0.1mol ? L~(-1) HCl,PBS6.8,0.5% pectin enzyme solution were determined by UV spectrophotometry with detection wavelengths of 303,330,298nm respectively.There was a good linear relationship between drug concentration of 5-ASA and adsorption A in the range of 10—40μg ? mL~(-1) with correlation coefficients of 0.9999, 0.9999,0.9997,respectively,and recoveries of different medium were greater than 98%with RSD less than 1%.The method has simple operation,accurate resultsand,can be applied to determination of content of 5-ASA preparation.

Key concepts: Chemistry, Spectrophotometry, Chromatography, Linear relationship, Aminosalicylic acid, Linear range, Linear correlation, Adsorption

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