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2003•Central Plains Medical JournalRequires access

The Study of Combined Serum Tumor Markers in Diagnosis of ovarian epithelial cancer

Huang Wen

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Abstract

Objective To discuss the value of alone and combined detection of CA125 and CA19-9 in the diagnosis of ovarian epithelial cancer.Methods Using the chemiluminescence immunoassay,we measured preoperative serum levels of CA125 and CA19-9 in 34 patients with ovarian epithelial cancer and 22 patients with benign ovarian tumor.We also assayed serum from 30 healthy women.Results The average levels of CA125 and CA19-9 in patients with epithelial ovarian cancer were 177.21±232.01 and 230.30±276.31,and higher than other groupes.CA19-9 was clearly superior in diagnosing mucinous carcinomata,the positive rate was 91.7% versus 75% for CA125.The Combined of the two markers increased the senditivity,specificity and accuracy to 88.2%?98.1% and 94.2%.Conclusion Paralled use of CA125 and CA19-9 could improve the diagnostic accuracy in ovarian epithelial cancer.

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Objective To discuss the value of alone and combined detection of CA125 and CA19-9 in the diagnosis of ovarian epithelial cancer.Methods Using the chemiluminescence immunoassay,we measured preoperative serum levels of CA125 and CA19-9 in 34 patients with ovarian epithelial cancer and 22 patients with benign ovarian tumor.We also assayed serum from 30 healthy women.Results The average levels of CA125 and CA19-9 in patients with epithelial ovarian cancer were 177.21±232.01 and 230.30±276.31,and higher than other groupes.CA19-9 was clearly superior in diagnosing mucinous carcinomata,the positive rate was 91.7% versus 75% for CA125.The Combined of the two markers increased the senditivity,specificity and accuracy to 88.2%?98.1% and 94.2%.Conclusion Paralled use of CA125 and CA19-9 could improve the diagnostic accuracy in ovarian epithelial cancer.

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Available abstract

Objective To discuss the value of alone and combined detection of CA125 and CA19-9 in the diagnosis of ovarian epithelial cancer.Methods Using the chemiluminescence immunoassay,we measured preoperative serum levels of CA125 and CA19-9 in 34 patients with ovarian epithelial cancer and 22 patients with benign ovarian tumor.We also assayed serum from 30 healthy women.Results The average levels of CA125 and CA19-9 in patients with epithelial ovarian cancer were 177.21±232.01 and 230.30±276.31,and higher than other groupes.CA19-9 was clearly superior in diagnosing mucinous carcinomata,the positive rate was 91.7% versus 75% for CA125.The Combined of the two markers increased the senditivity,specificity and accuracy to 88.2%?98.1% and 94.2%.Conclusion Paralled use of CA125 and CA19-9 could improve the diagnostic accuracy in ovarian epithelial cancer.

Key concepts: Ovarian cancer, Medicine, Epithelial ovarian cancer, Internal medicine, CA19-9, Tumor marker, Cancer antigen, Chemiluminescent immunoassay

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