A parallel control study of sertraline and paroxetine in the treatment of first-episode depression for 24 weeks

Objective: To compare the efficacy and safety of sertraline and paroxetine in the treatment of first-episode depression.Methods: 104 patients with first-episode depression were randomly cliviclecl into sertraline group(n=61) and paroxetine group(n=43).In the 24-week treatrnent,the Hamilton Depression Scale(HAMD) ware used to assesse the therapeutic efficacy,and the Treatment Emerget Symptom Scale(TESS) used to evaluate the adverse reactions.Results: Sertraline group was 77% efficiency,the efficiency of paroxetine group was 73%,between the two groups showed no significant difference.HAMD scores were compared before and after treatment were significantly different,between the two groups showed no significant difference.TESS scores between two groups of adverse effects on the individual items were significantly different.Conclusion: Sertraline and paroxetine in the treatment episode depression have good efficacy,but from the perspective of adverse reactions sertraline may be more suitable for long-term treatment of depression.