Ganlixin combined with glutathione for treatment of anti-tuberculosis drug-induced liver injury

Objective To observe the efficacy of ganlixin combined with glutathione for treatment of anti-tuberculosis drug-induced liver injury.Methods Sixty-three cases of anti-tuberculosis drug-induced liver injury patients were randomly divided into two groups.The treatment group were used ganlixin injection and glutathione injection intravenous drip.While the control group were treated with vitamin C injection and potassium-magnesium aspartate injection.The treatment were two weeks.To observe the two groups symptoms,signs and liver function changes before and after treatment.Results The treatment group's total efficiency was 96.9%,higher than that of the control group who's total efficiency was 74.2%(P0.05).In the treatment group after treatment ALT,AST,TBIL significantly improved(P0.01) than the pre-treatment and this decline were better than the control group(P0.05).Conclusion Ganlixin combined with glutathione for treatment of anti-tuberculosis drug-induced liver injury can improve the microcirculation of the liver,protect the liver cell damage.It is one of the effective ways in the clinical treatment of anti-tuberculosis drug-induced liver injury.