Analysis of loop electrosurgical excision procedure in the diagnosis and treatment for 41 cases of cervical carcinoma in situ

[Objective] To study the value of loop electrosurgical excision procedure (LEEP) in the diagnosis and treatment for cervical carcinoma in situ (CIS). [Methods] 41 cases diagnosed as CIS after LEEP conization were studied. 34 cases of them underwent hysterectomy or second conization and the pathology of their residual cervixes was analyzed. All the patients were followed up with liquid based thinprep cytological test (TCT) and colposcopy. [Results] On the margin of LEEP specimen, 75.6% was clear, 9.8% present cervical intraepithelial neoplasia (CIN) I, 9.8% present CIN II and 4.9% present CIS. The lesion remaining rate in the clean-margined group was 0, extremely lower than that in CIN-margined groups (χ2 =19.714, P =0.000). Following up for uterine-reserved patients after LEEP conization for 8~34 months, there was no recurrence. [Conclusions] LEEP conization with clean margin can aquire satisfied therapeutic effect. Ablative therapy for CIN is profitable for the avoiding of missed diagnosis of CIS.