Serum adiponectin and its relationship with risk factors in patients with coronary heart disease

Objective To test the serum adiponectin level and it's relationship with coronary risk factors in patients with coronary heart disease. Methods The coronary heart disease(CHD)groupcomprised 22 cases of stable angina pectoris(SAP), 32 cases of unstable angina pectoris(UAP), 36 cases of acute myocardial infarction(AMI). 30 healthy subjects served as control. Height, weight, waistline, hip rounds, fasting plasma glucose(FPG), insulin(FINS), total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C) and the level of serum adiponectin (APN) and body mass index (BMI), waist-to-hip ratio(WHR), insulin sensitivity index(ISI) were recorded. Results Serum adiponectin levels in the CHD Group was significantly lower than that in the conrol group, and the levels of serum adiponectin decreased gradually from SAP Group to AMI group.The SAP group had higher level of FINS and lower levels of ISI.The UAP group had higher levels of FINS, TC,TG, longer time of smoking cigarette and decreased ISI. The AMI group had higher levels of BIM, WHR, FINS, TC, TG, LDL-C, longer time of smoking cigarette and lower levels of ISI and HDL-C. Adiponectin concentrations were negatively correlated with BMI, WHR, FINS, TG, LDL-C and positively correlated with ISI and HDL-C. Conclusion The serum adiponectin level decreased in patients with CHD. The levels of serum adiponectin decreased and the risk factors increased with the progression of CHD. The levels of serum adiponectin in patients with CHD is close related with risk factors in CHD.