The research of prevention effect of fiveleaf gynostemma herb on the rabbits suffered from atherosclerosis and TESTO caused by high cholesterol feedstuff

Objective To study the effect of Fiveleaf Gynostemma Herb on the rabbits which suffered from atherosclerosis(As) and TESTO caused by high cholesterol feedstuff and to discuss the possible mechanism.Methods Forty rabbits were divided as the Fiveleaf Gynostemma Herb interverntion group(group A),Simvastain intervention group(group B),high blood lipids model group(group C),normal-control group(group E) at random,which were fed high fat food(92.5% standard feedstuff added 2% cholesterol,2% yolk and 3.5% lard) added Fiveleaf Gynostemma Herb(5 g/kg),high fat feedstuff added simvastain(5 mg/kg),high fat feedstuff and standard feedstuff respectively.TG,TC,LDL-C,HDL-C and TESTO were examined before the experiment and at the sixth and nineth week of the experiment.Aortic pathology and the thickness of endarterium of the amimals in each group were observed.Results①Blood lipids:with the feeding time prolonged,TG,TC and LDL-C of group A,group B and group C were growing gradually and had the prominent difference than ex-experiment(P0.05～0.01).HDL-C of group A and group B had the significant differnece(P0.01).TG,TC,LDL-C of group A and group B were lower than those in group C(P0.05～0.01).HDL-C of group A was superior to group C(P0.01);②Level of TESTO:TESTO of group A,group B,group C and group E had no difference before the experiment and at the sixth and nineth week of the experiment(P0.05);③Pathomorphological examination:the blood vessel of group E is smooth and had no atherosclerotic plaque;group C has many gray grease and it can be easily seen near the aorta;the atherosclerotic plaque area of group A and group B had distinctively decreased.The rate between atherosclerotic plaque and intima of group A,group B,group C and group E was(31±5)%,(32±6)%,(60±9)% and 0 respectively,the rate between intima and extima of group A,group B,group C and group E was(40±16)%,(41±15)%,(70±12)%、0,aortic intimal atherosclerotic plaque area and arterial intima thickness group A and group B of obviously reduced.Group A,group B and group C had the significant difference(P0.01).Conclusion Fiveleaf Gynostemma Herb had the similar intervention effect as the simvastain to the As rabbits caused by high cholesterol food and this effect was in relation to the adjusting the metabolism of the blood lipids and inhibitory the inflmmation reaction.Fiveleaf Gynostemma Herb had the difference in adjusting the metabolism of the blood lipids with Simvastain.