Clinical effect of large dose of ambroxol in treatment of acute episode of chronic bronchitis (AECB)

Objective To investigate the efficacy of large dose of ambroxol in the treatment of AECB.Methods One hundred and eight cases of AECB patients were randomly divided into study group and control group.The patients of two groups were all given conventional treatment.On the basis of conventional treatment,patients in the study group were given ambroxol hydrochloride injection 30 mg +5% glucose solution 250 mL intravenous infusion,3 times/d;patients in the control group were given ambroxol hydrochloride injection 7.5 mg +5% glucose solution 250 mL intravenous infusion,3 times/d.They were all treated for 7 to 10 days.The treatment effect,signs and symptoms extinction time,CRP,IL-8,TNF-α changes of two groups were observed.Results The symptoms and signs extinction time of study group were significantly shorter than control group,the difference was statistically significant(P 0.05);CRP,IL-8,TNF-α of two groups were all reduced after treatment,but the CRP,IL-8,TNF-α level of study group was significantly lower than control group,the difference was statistically significant;The total effective rate of study group and control group were 92.6% and 74.1%,the difference between the two groups was statistically significant(P 0.05).Conclusion The effect of large dose of ambroxol injection in adjuvant treatment of AECB is good,the symptoms extinction time is short,the safety is high,so it is worthy of clinical application.