Clinical significance of four coagulation tests and the D-dimer test in patients with liver cirrhosist

Objective To investigate the value of clinical applications of four coagulation tests and the D-dimer test in patients with liver cirrhosis.Methods 95 cases of liver cirrhosis(51 cases in compensated cirrhosis group and 44 cases in decompensated cirrhosis group) and 65 healthy people in control group underwent determinations of the prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen concentration(FBG),thrombin time(TT) and the levels of D-dimer in our hospital.The results were compared and analyzed.Results Compared with the control group,PT,APTT and TT in the cirrhosis group were significantly prolonged(P0.05),FBG was significantly lower(P0.05) and the levels of D-dimer were significantly higher(P0.05);Compared with the compensated cirrhosis group,PT,APTT and TT in the decompensated cirrhosis group were significantly prolonged(P0.05),FBG were significantly lower(P0.05),and the levels of D-dimer were significantly higher(P0.05).Conclusion The combined determination of four coagulation tests and the D-dimer are clinically significant to the judgment of disease conditions,the treatment and the prevention of hemorrhage in patient with liver cirrhosis.