Clinical significance of four coagulation tests and D-dimer test in liver cirrhosis patients

Objective: To investigate the clinical applications of four coagulation tests and D-dimer test in patients with liver cirrhosis. Methods: Four coagulation tests and the D-dimer test were performed in 216 patients with liver cirrhosis(62 in Child-Pugh A group,88 in B group and 66 in C group) and 84 healthy individuals by Sysmex Cs-5100 auto blood coagulation analyzer. Results: Compared with the control group,the prothrombin time(PT),activated partial thromboplastin time(APTT) and thrombin time(TT) in liver cirrhosis group were significantly prolonged(P 0. 05),the fibrinogen(FIB) was significantly lower(P 0. 05),and the D-dimer level was significantly higher(P 0. 05). Conclusion: The four blood coagulation indexes and serum Ddimer level are correlated with disease status of liver cirrhosis. The combination detection of blood coagulation function and serum D-dimer may be significantly useful for the assessment of disease condition,the treatment and prevention of hemorrhage in upper digestive tract and the prediction of prognosis for cirrhosis patients.