Study on the Effect of Ginsenoside Rg3 on Immune Function of Tumor-Bearing Mice

Objective To investigate the effect of Ginsenoside Rg3 on the immune function of tumor-bearing mice with lung cancer.Methods Forty-eight tumor-bearing mice with C57BL/6 lung cancer were randomly divided into four groups,high-dose Ginsenoside Rg3 group(Rg3,15 mg/kg),low-dose Ginsenoside Rg3 group(Rg3,5 mg/kg),cisplatin(DDP) group(DDP,0.5 mg/kg) and saline group.The activities of splenic natural killer(NK) cells,lymphokine activated killer(LAK) cells,cytotoxic T lymphocyte(CTL),and serum tumor necrosis factor(TNF) level were detected in each group after the administration of tumor-bearing mice was performed.Twelve normal mice as control group.Results The positive rates of Survivin of low-dose Rg3 group,high-dose Rg3 group,DDP group were significantly lower than that of saline group(P0.05);Tumor mass of low-dose Rg3 group,high-dose Rg3 group was less than that of saline group(P0.05),but greater than that of DDP group(P0.01);The activities of NK,LAK and CTL,and serum TNF level decreased significantly in saline group compared with the normal controls(P0.05);The activities of NK,LAK and CTL,and serum TNF level of DDP group were lower than those of saline group(P0.05),which increased significantly in low-dose Rg3 group and high-dose Rg3 group compared with those of saline group,DDP group(P0.05),but lower than the normal controls(P0.05);There was no significant difference in the activities of NK,LAK and CTL,and serum TNF level between low-dose Rg3 group and high-dose Rg3 group(P0.05).Conclusion Ginsenoside Rg3 can improve specific anti-tumor immune response in tumor-bearing mice significantly.