Experimental Study on the Effect of Astragalus Polysacchari on Anti-tumor

OBJECTIVE The aim of this study was to explore the effect of Astragalus polysacchari(APS) on anti-tumor in the mice with tumor and its mechanism of anti-tumor.METHODS Fifty mice were divided into five groups randomly: negative group,positive group,low dose group,median dose group and high dose group respectively.After the mice model with tumor were constructed,the mice in negative group were given normal saline the mice in positive group were given cyclophosphamide,the other experimental groups were given different dose of ASP.The parameters of tumor inhibited rate,proliferative T cell responses,cytotoxicity of NK cell were observed.RESULTS (1) With the dose of ASP increased,tumor inhibited rate became higher and higher(P0.05).(2) The parameters of proliferative T cell responses,cytotoxicity of NK cell of the three experimental group were higher than those of the positive group.Moreover,in the three experimental groups,with the dose becoming high,the two parameters increased.CONCLUSION Asp could inhibit the tumor in mice through the way of strengthening the level cell immunity.