Clinical Analysis of Elderly Patients with Chronic Obstructive Pulmonary Disease with Nosocomial Pulmonary Fungal Infection

Objective To investigate the possible risk factors of nosocomial pulmonary fungal infection,infection time,the clinical features,common infection fungal and prognosis of elderly patients with chronic obstructive pulmonary disease(COPD).Methods The clinical data of 36 patient of COPD complicated with nosocomial pulmonary fungal infection over 65 years old and 40 patients without nosocomial pulmonary fungal infection were retrospectively analyzed.Results Long-term use of broad-spectrum antibiotics and(or)glucocorticoid,hypoalbuminemia,neutropenia,smoking for a long time,and hospitalizations were risk factors for nosocomial pulmonary fungal infection in elderly COPD patients.In about 1/3 of patients,nosocomial pulmonary fungal infection occurred within one to two weeks of hospitalization.The clinical features were non-specific.Pathogens were mainly Candida albicans(80.55%).Bronchial pneumonia and group block were the main findings in Chest X-ray.The prognosis was poor.Conclusion Elderly patients with COPD are prone to nosocomial pulmonary fungal infection if they have hypoproteinemia,neutropenia or use long-term broad-spectrum antibiotics and(or)glucocorticoids.