Risk factors of Nosocomial Pulmonary Fungal Infection in COPD Patients

Objective To investigate the risk factors and the immune functions for nosocomial pulmonary fungal infection(PFI)in COPD patients.Methods The data of 42 cases of nosocomial PFI were analyzed to examine the level of T lymphocyte substs(TLS)in pe-ripheral blood from 53 cases of COPD,and then to compare with 40 healthy donors.Results Nosocomial pulmonary fungal infection was ranked candida albicans as the first pathogen.CD3 and CD4 of COPD with PFI were significantly lower than COPD and heathly donors(P﹤ 0.05).According to univariate analysis,the risk factors associated with nosocomial pulmonary fungal infection included those of long term use of broad-spectrum antibiotics,long term use of adrenocortical steroid,diabetes mellitus,type II respiratory failure and hypoalbuminemia.Conclusions The important measures are reasonable use of broad spectrum antibioticsm,corticosteroids and anti-fungal,effective improve-menrf of the immune levels,treatment of basical diseases such as diabetes,respiratory failure and COPD to reduce incidence of pulmonary fungal infection.