Expressions of PTEN,PI3K and Akt protein in bladder carcinoma and their clinical significance

Objective:To investigate the expressions of PTEN,PI3K and Akt proteins in bladder transitional cell carcinoma(BTCC)and their clinical significance.Methods:SP immunohistochemical method was used to detect expressions of PTEN,PI3K and Akt proteins in ten normal bladder mucosa specimens and 60 BTCC specimens.Results:The positive rates of PTEN,PI3K and Akt proteins in 60 BTCC specimens were 58.33%(35/60),71.67%(43/60)and 56.67%(34/60)respectively.There were significant differences of PTEN,PI3K and Akt proteins expressions between bladder carcinoma and normal bladder epithelium(all P0.05).In 60 cases of bladder carcinoma,a negative correlation was found between the expression of PTEN and PI3K or Akt proteins respectively(both P0.05),and there was a highly positive correlation between PI3K and Akt protein exp ression(P=0.001).Conclusion:The expressions of PTEN,PI3K and Akt proteins were related with the development,progress and invasiveness of bladder carcinoma.The loss of PTEN protein expression may be related with the over expression of Akt protein.PI3K and Akt protein may cooperate to promote malignant progress of bladder carcinoma.