Observation on the Immunity Effects With Different Hepatitis B Vaccine Made by Recombinant DNA Techniques

Objective To evaluate the immunity effects with different hepatitis B vaccine made by recombinant DNA techniques in college students and children.Methods The serological epidemical survey was used in this study to evaluate the immunity effects with different hepatitis B vaccine.Results College students who had not been immunized by Hepatitis B before and the children who had been immunized by Hepatitis B before were inoculated by different hepatitis B vaccine made by recombinant DNA techniques.In the college students,the average anti-HBs positive rate was 95.5 0% and the range was from 91.60%-97.10%.The Vaccine Dalian was higher than Kangtai.The geometrical mean concentration(GMC)had no statistical difference on the four kinds of Hepatitis B.In the children,the average anti-HBs positive rate was 98.30% and the range was from 96.60% to 100.00%.The anti-HBs positive rate and GMC of the four different vaccines were nearly the same.The immunity effects with different hepatitis B vaccine made by recombinant DNA techniques in college students and children were perfect.The anti-HBs positive rate and GMC of the hepatitis B vaccines was high both in the college students who had not been immunized by Hepatitis B before and in the children who had been immunized by Hepatitis B before.The immune memory was good in the children and had protective effect.It was not necessary to make booster immunization in these children.