2003•Journal of Guangdong Medical CollegeRequires access

Effect of paclitaxel on fibroblast proliferation and collagen gene expression in human hypertrophic scar

Wu Zhi

Abstract

Objective:To investigate the effect of paclitaxel on fibroblast proliferation and type Ⅰ and type Ⅲ procollagen mRNA expression in human hypertrophic scar.Methods: Proliferation and type Ⅰ and type Ⅲ procollagen mRNA expression in cultured fibroblasts from human hypertrophic scar were determined by MTT method and RT PCR,respectively.Results: Paclitaxel treatment resulted in significant inhibition of proliferation and type Ⅰ and type Ⅲ procollagen mRNA expression in cultured fibroblasts in a dose dependent manner.Conclusion: Paclitaxel could reduce the hypertrophic scarring via inhibiting fibroblast proliferation and type Ⅰ and type Ⅲ procollagen mRNA expression.

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Key concepts: Fibroblast, Paclitaxel, Procollagen peptidase, Hypertrophic scar, Messenger RNA, Cell growth, Type I collagen, Molecular biology