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Research of echistatin effect on human hypertrophic scar-derived fibroblasts

Huang Xiao-yuang

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Abstract

[Objective] To investigate the effect of echistatin on proliferation, apoptosis, and type Ⅰand type Ⅲ procollagen mRNA expression in human hypertrophic scar-derived fibroblasts. [Methods] After treated by echistatin, proliferation, apoptosis, type Ⅰ/type Ⅲ procollagen mRNA expression in cultured fibroblasts from human hypertrophic scar were determined by MTT method, Flow cytometry , and RT-PCR respectively. [Results] Echistatin treatment resulted in significant inhibition of proliferation, type Ⅰ/type Ⅲ procollagen mRNA expression, and marked apoptosis in cultured hypertrophic scar-derived fibroblasts. [Conclusion] Echistatin may be chosen as a drug to prevent and cure hypertrophic scar.

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What this paper is about

[Objective] To investigate the effect of echistatin on proliferation, apoptosis, and type Ⅰand type Ⅲ procollagen mRNA expression in human hypertrophic scar-derived fibroblasts. [Methods] After treated by echistatin, proliferation, apoptosis, type Ⅰ/type Ⅲ procollagen mRNA expression in cultured fibroblasts from human hypertrophic scar were determined by MTT method, Flow cytometry , and RT-PCR respectively. [Results] Echistatin treatment resulted in significant inhibition of proliferation, type Ⅰ/type Ⅲ procollagen mRNA expression, and marked apoptosis in cultured hypertrophic scar-derived fibroblasts. [Conclusion] Echistatin may be chosen as a drug to prevent and cure hypertrophic scar.

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Available abstract

[Objective] To investigate the effect of echistatin on proliferation, apoptosis, and type Ⅰand type Ⅲ procollagen mRNA expression in human hypertrophic scar-derived fibroblasts. [Methods] After treated by echistatin, proliferation, apoptosis, type Ⅰ/type Ⅲ procollagen mRNA expression in cultured fibroblasts from human hypertrophic scar were determined by MTT method, Flow cytometry , and RT-PCR respectively. [Results] Echistatin treatment resulted in significant inhibition of proliferation, type Ⅰ/type Ⅲ procollagen mRNA expression, and marked apoptosis in cultured hypertrophic scar-derived fibroblasts. [Conclusion] Echistatin may be chosen as a drug to prevent and cure hypertrophic scar.

Key concepts: Hypertrophic scar, Flow cytometry, Medicine, Procollagen peptidase, Apoptosis, Messenger RNA, Pathology, Endocrinology

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