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DETERMINATION OF INTERLEUKIN-6 IN SERUM OF PATIENTS WITH PREGNANCY-INDUCED HYPERTENSION

Fuling Wang

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Abstract

Objective To study the changes of serum interleukin-6(IL-6) in patients with pregnancy-induced hypertension(PIH) and the relationship between IL-6 and the genesis of PIH. Methods Serum levels of IL-6 of 60 PIH women (including 20 with mild PIH, 20 moderate, and 20 severe) and 35 normal pregnant ones were measured by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-6 in the PIH group were significantly higher than those in the control group (t= 2.165 ,P0.05). Serum levels of IL-6 in the moderate and severe PIH groups were significantly higher than those in the mild PIH group and control group (F=8.412,q=4.365-6.053,P0.05,0.01). No difference existed between the serum levels in the mild PIH and control groups (q=2.102,P0.05). Conclusion The increased levels of serum of IL-6 may participate in the vascular endothelium damages in PIH. IL-6 may play a role in the genesis of PIH.

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What this paper is about

Objective To study the changes of serum interleukin-6(IL-6) in patients with pregnancy-induced hypertension(PIH) and the relationship between IL-6 and the genesis of PIH. Methods Serum levels of IL-6 of 60 PIH women (including 20 with mild PIH, 20 moderate, and 20 severe) and 35 normal pregnant ones were measured by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-6 in the PIH group were significantly higher than those in the control group (t= 2.165 ,P0.05). Serum levels of IL-6 in the moderate and severe PIH groups were significantly higher than those in the mild PIH group and control group (F=8.412,q=4.365-6.053,P0.05,0.01). No difference existed between the serum levels in the mild PIH and control groups (q=2.102,P0.05). Conclusion The increased levels of serum of IL-6 may participate in the vascular endothelium damages in PIH. IL-6 may play a role in the genesis of PIH.

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Available abstract

Objective To study the changes of serum interleukin-6(IL-6) in patients with pregnancy-induced hypertension(PIH) and the relationship between IL-6 and the genesis of PIH. Methods Serum levels of IL-6 of 60 PIH women (including 20 with mild PIH, 20 moderate, and 20 severe) and 35 normal pregnant ones were measured by enzyme-linked immunosorbent assay(ELISA). Results Serum levels of IL-6 in the PIH group were significantly higher than those in the control group (t= 2.165 ,P0.05). Serum levels of IL-6 in the moderate and severe PIH groups were significantly higher than those in the mild PIH group and control group (F=8.412,q=4.365-6.053,P0.05,0.01). No difference existed between the serum levels in the mild PIH and control groups (q=2.102,P0.05). Conclusion The increased levels of serum of IL-6 may participate in the vascular endothelium damages in PIH. IL-6 may play a role in the genesis of PIH.

Key concepts: Medicine, Internal medicine, Pregnancy, Endocrinology, Gastroenterology, Genetics, Biology

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