Affect of Spontaneously Hypertensive Rat Cardiomyocyte Expression of PPAR-γ and GLUT-4 with Atorvastatin

Objective: To analyse affect of spontaneously hypertensive rat cardiomyocyte expression of PPAR-γ and GLUT- 4 with atorvastatin,in order to provide theoretical guidance for clinical application.Method: 20 spontaneously hypertensive rats were randomly divided into group A( 10) and group B( 10),10 healthy rats were selected as group C. Group A were feeded with atorvastatin in dose of 50mg·kg-1·d-1by gavaging,group B and group C were feeded with the same amount of distilled water by gavaging. Systolic and diastolic blood pressure values of the three groups were measured every other week until 10 weeks; Lipid levels and left ventricular mass index of three groups were measured for 10 weeks,Lipid levels of three groups were compared; PPAR-γ and GLUT-4 expression levels of three groups were detected by immunohistochemistry and PT-PCR method. Result: Diastolic and systolic blood pressure levels in group A and group B rats were higher than group C rats( P 0.05),group A and group B median level of blood pressure had no significant( P 0.05); lipid levels of TC,TG,HDL-C and LDL-C in group A and group B were lower than group C rats( P 0.05),lipid levels had no relatively difference between group A and group B( P 0.05).LVM1 levels among three groups were significant differences( P 0. 05),and group B was the highest,group A was Secondly higher,group C was the lowest; before the intervention,PPAR-γ and GLUT- 4 expression of group A and group B was lower than group C( P 0.05),but group A and group B were not significant( P 0. 05); after the intervention,PPAR- γ and GLUT- 4 expression levels was significantly increased,there was not significant compared with group C,but there was significant different compared with group B( P 0.05). Conclusion: Atorvastatin fed spontaneously hypertensive rats,can reduce the level of left ventricular mass index,blood pressure,but no significant effect on blood lipid levels,which may increase PPAR-γ and GLUT-4 expression levels,the specific mechanisms needed further study.