Comparative Study on CEA Results from Different Detection System

Objective:To compare the CEA results from different detection systems. Methods:4 different chemiluminescence immune detection systems ( Bayer ACS:180, Bayer ADVIA Centuar, Johnson Vitron Eci and DPC IMMULITE ) were used to detect CEA concentrations in 3 kinds of quality control specimen ( Bayer,DPC and self-made) and 32 patient samples. The collected data were processed by statistics analysis.Results: Analysis of variance showed that CEA results from different controls and patient samples were significant different among different detection systems (P0.01). The correlation coefficient of each detection system was above 0.975 and the reliability coefficient was close to 1. When Johnson Vitron Eci was used as standard detection system to evaluate the acceptability of other detection system, Bayer ADVIA Centuar was partly acceptable clinically, however, Bayer ACS:180 and DPC IMMULITE were not reliable.Conclusions:The precision of CEA results in 4 kinds of detection system gave a good fit to clinic requirement. However, incomparability existed in the evaluation of clinical acceptability.