Influence of morning blood pressure surge on early renal damage in senile patients with essential hypertension

Objective To investigate the influence of morning blood pressure surge (MBPS) on early renal damage in senile patients with essential hypertension.Methods The patients (n=134) were divided into the MBPS group and non-MBPS group according to the results of 24-hour ambulatory blood pressure monitoring.The changes of blood fat,fasting plasma glucose,urine micro albumin (mAlb),plasma β2-microglobulin (β2-MG),cystatin C,serum creatinine (Scr) and ambulatory blood pressure monitoring were detected,and body mass index (BMI) was calculated.Results In the MBPS group,the average systolic pressure of 24 hours,day time and evening were higher significantly than those in the non-MBPS group (P0.05).The levels of plasma β2-MG,urine mAlb and serum cystatin C were higher in the MBPS group than those in the non-MBPS group and the difference was significant statistically (P0.05).The changes of BMI,blood fat,fasting plasma glucose and Scr was not significant.Conclusion The hypertensive patients with MBPS have more risk of early renal damage than those without MBPS.