Clinical Observation of Ornithine Aspartate in Treatment of Hepatic Encephalopathy

Objective To explore the clinical efficacy of ornithine aspartate in treatment of hepatic encephalopathy.Methods Sixty patients with hepatic encephalopathy admitted during July 2011 and March 2012 to our hospital were randomly divided into therapy group(n=30) and control group(n=30).Therapy group was treated with ornithine aspartate injection,while control group was treated with potassium glutamate injection and sodium glutamate injection.The clinical efficacy of the two groups was compared according to Child grade of hepatic encephalopathy.Results The total effective rate of therapy group was 90% while the control group was 50%,and the differences was statistically significant(χ2=11.429,P=0.001).The blood ammonia and liver function of therapy group showed an obvious descent in different Child grades,but had significant difference when compared with that of the control group(P=0.000,P0.05).The treatment effectiveness of different hepatic encephalopathy grades were compared,and there was no statistical significance in grade Ⅰ and grade Ⅳ(P0.05).The treatment effectiveness of grade Ⅱ and grade Ⅲ had an advantage over that of control group(P0.05).Conclusion Ornithine aspartate is safe and has better effect in treatment of hepatic encephalopathy than potassium glutamate and sodium glutamate.