Influence of Wind-dispelling Therapy on Therapeutic Effect of Blood-cooling and Kidney-tonifying Herbs for Idiopathic Thrombocytopenic Purpura

Objective To observe the influence of wind-dispelling therapy on therapeutic effect of blood-cooling and kidney-tonifying herbs for chronic idiopathic thrombocytopenic purpura(CITP),and to investigate its immunoregulatory effect.Methods Forty-two CITP patients were randomized into 2 groups:the treatment group(N=22) received therapy of dispelling wind,cooling blood and tonifying kidney,and the control group(N=20) received therapy of cooling blood and tonifying kidney.Six weeks constituted one treatment course,and the treatment lasted 3 courses.Serum interleukin 2(IL-2),soluble IL-2 receptor(sIL-2R),Fas protein,Fas-L protein,and platelet-associated immunoglobulin G(PAIgG) levels and lymphocyte subtypes were compared before and after treatment.Results In the treatment group,14 patients were clinically cured,5 markedly effective,2 effective,1 ineffective and the total effective rate was 95.5%;in the control group,8 patients were clinically cured,4 markedly effective,3 effective,5 ineffective and the total effective rate was 75.0%.The therapeutic effect in the treatment group was superior to that in the control group(P0.05).Serum IL-2 level was increased,and sIL-2R decreased in the two groups after treatment(P0.01 compared with those before treatment),and the above changes were obvious in the treatment group(P0.05).The protein expression of platelet Fas and Fas-L and PAIgG level was down-regulated(P0.01 compared with that before treatment),and the effect was obvious in the treatment group(P0.05).T Lymphocyte subtype CD+4 percentage and CD+4/CD+8 ratio were increased,and CD+8 percentage was decreased in the two groups after treatment(P0.05 compared with those before treatment).Conclusion Therapy of dispelling wind can enhance the therapeutic effect of blood-cooling and kidney-tonifying herbs for chronic idiopathic thrombocytopenic purpura.