Expression of CD105 and Matrix Metalloproteinases 2 in Adenoid Cystic Carcinoma and Significance to Prognosis

Objective: To investigate expression of CD105 (endoglin, marker of microvessel density,MVD), matrixmetalloproteinase-2 (MMP-2) in salivary adenoid cystic carcinoma (ACC) and the relations to clinic pathology and prognosis. Methods: Samples were selected from parotid glands of 41 cases of ACC, 27 cases of benign tumor and 23 normal cases. Expression of CD105 and MMP-2 were detected by immunohistochemistry. Relationship between their expression and the pathological changes, survive condition were analyzed. Results: No expression of CD105 or MMP-2 were detected in normal glands. The level of CD105 and MMP-2 expressed in ACC group were both higher than those in benign tumor group. MVD represented by CD105 had a positive correlation with both the histological type and clinical stage, while MMP-2 only related with clinical stage. Results of Cox regression showed expression of CD105 might play independent vole in ACC prognosis, but the same conclusion was not drawn in MMP-2. Significant difference in recurrence rate between high and low expression of CD105 were noted. There was positive correlation between expression of CD105 and MMP-2. Conclusion: CD105 may be used as possible prognostic factor of tumor recurrence. Over expression of MMP-2 has relation with ACC local invasion.