Effects of losartan on left ventricular hypertrophy and left veutricular diastolic function in hypertension

Objective To investigate the effect of losartan on left ventricular hypertrophy and left ventricular diastolic function in hypertension.Methods Thirty-two essential hypertension patients(WHO classⅡ)were treated with losartan for eight weeks.Plasma renninactivity,angiotensin Ⅱ(AngⅡ),aldosterone and procolagen Ⅲ were determined.The left ventricular mass and ventricular function were monitored by color Doppler cardiography.Results Levels of aldosterone were decreased significantly.The ratio of peak velocity was increased at rapid filling(E) and atrial contraction(A).The thickness of interventricular septum(IVS)and posterior wall,left ventricular mass index did not alter.Conclusion Blood pressure,procolagen Ⅲ and the diastolic function are improved after the treatment by losartan.