The efficacy comparison of esomeprazole and omeprazole to treat with the patients helicobacter pylori(Hp) positive chronic gastritis

OBJECTIVE Compared the clinical efficacy of esomeprazole and omeprazole to treat the patients with Helicobacter pylori(Hp) positive chronic gastritis.METHODS 66 patients with chronic gastritis from February 2009 February 2011 in our hospital were randomly divided into control group and observation group,and each group had 33 cases.The control group was given omeprazole,amoxicillin and clarithromycin while the observation group was given esomeprazole,amoxicillin and clarithromycin.The clinical efficacy,Hp eradication rate,abdominal pain erasing and adverse reactions were compared between the two groups.RESULTS The total effective rate and the Hp eradication rate in the observation group were 96.97% and 93.94% higher than 90.91% and 90.91% of the control group,the adverse reaction rate was 6.06% lower than 12.12% of the control group,however,there were no statistically significance differences between the two groups(P0.05);the abdominal pain easing rate was 75.76% higher than 30.30% of the control group(P0.05).CONCLUSION The clinical efficacy of esomeprazole and omeprazole for treating with Hp positive chronic gastritis is roughly equal;however,the onset of esomeprazole is more rapid and obvious than esomeprazole,and it is a good choice to treat with Hp positive chronic gastritis.