Comparative study on aripiprazole and quetiapine in the treatment of first-episode schizophrenia

Objective To compare the curative effect and safety of aripiprazole and quetiapine in the treatment of first-episode schizophrenia.Methods 80 cases of first-episode schizophrenia were randomly divided into aripiprazole group and quetiapine group,each group had 40 cases.A period of treatment was 8 weeks.The curative effect and sideeffects were respectively evaluated at baseline and the 2nd,4th,6th and 8th week of treatment by using positive and negative syndrome scale(PANSS),clinical global impression scale(CGI)and toxic effects symptoms scale(TESS).Results(1)The clinical total effective rate of aripiprazole group and quetiapine group at the 8th week of treatment was 87.5%,85.0% respectively,and the difference was not statistically significant(P 0.05).(2)Compared with baseline,the CGI-SI of two groups from the 2th week of treatment decreased(P 0.05);The difference was not significant in the CGI-SI at different time points between two groups(P 0.05);(3)The incidence of side-effects of aripiprazole group and quetiapine group was 20.0%,22.5% respectively,and the difference was not statistically significant(P 0.05).The incidence of drowsiness and heart rate of quetiapine group were higher than those of aripiprazole group.Conclusion Aripiprazole and quetiapine in the treatment of first-episode schizophrenia have better curative effect,light adverse reaction,good tolerance,and it is worthy of clinical recommended use.