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2005•Pharmaceutical Journal of Chinese People's Liberation ArmyRequires access

Effect of Tiandong Jiangtang Capsule on Alloxan-induced Islet Injury in Diabetic mice

Yang Xin

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Abstract

Aim To observe the effect of Tiandong Jiangtang capsule on alloxan-induced islet injury in diabetic mice.Methods Mice were injected iv with alloxan 90 mg·kg -1 to induce diabetic model.After intoxicated,the mice were treated with Tiandong Jiangtang capsule.The blood and pancreas were taken after 14d treatment.Blood glucose and amylase was determined by Automatic Biochemistry Analysor.Pancreas and islet were examined under microscope.Results The treatment with Tiandong Jiangtang capsule at the doses of 10 and 20g·kg -1 ig could decrease the Glu and increased amylase significantly.Under the light microscopy,the size and cell number of islets were reduced in control group,while those in Tiandong Jiangtang capsule-treated group manifested approximate normal pathology.Conclution Tiandong Jiangtang Capsule has the effects of hypoglycemication and islet-protection.

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What this paper is about

Aim To observe the effect of Tiandong Jiangtang capsule on alloxan-induced islet injury in diabetic mice.Methods Mice were injected iv with alloxan 90 mg·kg -1 to induce diabetic model.After intoxicated,the mice were treated with Tiandong Jiangtang capsule.The blood and pancreas were taken after 14d treatment.Blood glucose and amylase was determined by Automatic Biochemistry Analysor.Pancreas and islet were examined under microscope.Results The treatment with Tiandong Jiangtang capsule at the doses of 10 and 20g·kg -1 ig could decrease the Glu and increased amylase significantly.Under the light microscopy,the size and cell number of islets were reduced in control group,while those in Tiandong Jiangtang capsule-treated group manifested approximate normal pathology.Conclution Tiandong Jiangtang Capsule has the effects of hypoglycemication and islet-protection.

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Available abstract

Aim To observe the effect of Tiandong Jiangtang capsule on alloxan-induced islet injury in diabetic mice.Methods Mice were injected iv with alloxan 90 mg·kg -1 to induce diabetic model.After intoxicated,the mice were treated with Tiandong Jiangtang capsule.The blood and pancreas were taken after 14d treatment.Blood glucose and amylase was determined by Automatic Biochemistry Analysor.Pancreas and islet were examined under microscope.Results The treatment with Tiandong Jiangtang capsule at the doses of 10 and 20g·kg -1 ig could decrease the Glu and increased amylase significantly.Under the light microscopy,the size and cell number of islets were reduced in control group,while those in Tiandong Jiangtang capsule-treated group manifested approximate normal pathology.Conclution Tiandong Jiangtang Capsule has the effects of hypoglycemication and islet-protection.

Key concepts: Islet, Alloxan, Capsule, Pancreas, Endocrinology, Internal medicine, Amylase, Diabetes mellitus

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Effect of Tiandong Jiangtang Capsule on Alloxan-induced Islet Injury in Diabetic mice — Research Paper | ScholarLens