Comparison of Effects of Loading Dose Rosuvastatin versus Atorvastatin Therapy in Non-ST Segment Elevation Acute Coronary Syndrome Patients

Objective To assess the effect of different loading doses of rosuvastatin and atorvastatin treatment in non-ST segment elevation acute coronary syndrome patients during PCI.Methods A total of 188 patients with non-ST segment elevation acute coronary syndrome were randomly assigned to either rosuvastatin group(30 mg before PCI) or atorvastatin group(120 mg before PCI).Periprocedural myocardial injury,hs-CRP,IL-1,IL-6,TNF-α,and the incidence of major adverse cardiac events(MACE) were assessed.Results The MACE at 3 and 6 months after operation,the incidence of periprocedural myocardial injury and the inflammation factor levels were lower in rosuvastatin group than the atorvastatin group.Conclusion Compared with atorvastatin group,high loading dose of rosuvastatin therapy showed better effects of anti-inflammation and cardiac protection,and significantly reduced the MACE incidence at both 3 and 6 months after operation.