Effect of Carvedilol on Congestive Heart Failure in Patients with Dilated Cardiomypathy

Objective To determine the clinical effects of carvedilol in patients with congestive heart failure(CHF).MethodsAll 60 patients with CHF secondary to dilated cardiomyopathy(DCM)were treated with digitalis,diuretics,ACEI and/or nitroglycerin,and were randomly divided into ① carvedilol group additionally,treated with carvedilol;②conventional treatment group:additionally receiving placebo.The fraction shortening(FS),left ejection fraction(EF),stroke volume(SV),left ventricular diastolic dimension(LVDD),interventricular septum(IVS)and left ventricular posterior wall(LVPW)were measured with echocardiography before and 4 months after treatment.Results After treatment for 4 months,the cardiac function improved markedly in both groups,but that of carvedilol group improved more significantly than that of conventional group,such as LVDD(61.5±6.6 vs 67.3±6.2,P0.05),EF(48±9.7 vs 40.3±6.2,P0.05),D/T(4.1±0.7 vs 4.6±0.5,P0.05).Conclusions Carvedilol possesses protective effect on cardiac function and myocardium remodeling in patients with CHF.