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Observation of the effect of carvedilol in congestive heart failure in patients with dilated cardiomyopathy

Liu Kai-chun

Abstract

Objective:To investigate the clinical effect of carvedilol in the treatment of congestive heart failure(CHF) in patients with dilated cardiomyopathy(DCM).Methods:60 DCM patients with CHF were randomly divided into carvedilol group and control group on the basis of digitalis,diuretic,ACEI and nitro-glycerine treatment,with 30 cases in each group.The fraction shortening(FS),left ejection fraction(EF),strok volume(SV),left ventricular diastolic dimension(LVDD),interventricular septum(IVS) and left ventricular posterior wall(LVPW) in both groups were measured with echocardiography before and 4 months after treatment.Results:4 months after treatment,the cardiac funtion in both groups improved markedly,but that in carvedilol group improved more significantly compared with that in control group,such as LVDD(60.5±6.6 vs 67.3±6.1,P0.05),EF(47.8±9.7 vs 40.5±6.4,P0.05),and D/T(4±0.7 vs 4.5±0.5,P0.05).Conclusion:Carvedilol possesses protective effect on cardiac function and myocardium in DCM patients with CHF.

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Key concepts: Medicine, Carvedilol, Cardiology, Ejection fraction, Dilated cardiomyopathy, Heart failure, Internal medicine, Interventricular septum