2008Chinese Journal of PharmaceuticalsRequires access

Degradation Kinetics of Sodium Lauroyl-α-hydroxyethyl Sulfonate in Aqueous Solution

Yuling Liu

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Abstract

The HPLC method was used to investigate the degradation kinetic characters of sodium lauroyl-α-hydroxyethyl sulfonate(sodium neohouttuynin) at different pH buffer.With comparative regression analysis of linear fi t,the degradation met the second-order kinetics in pH 4.0 -11.0 phosphate buffer.It showed that the degradation rate(K) was influenced significantly by pH.The pH-K curve was bell-like.The degradation rate was fast at pH 7.0 -8.0 and sodium lauroyl-α-hydroxyethyl sulfonate was relatively stable in the solution at pH 4.0 or pH 11.0.Therefore,the degradation was not simply an acid-base catalytic reaction.There might be some speed control steps at particular pH.

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What this paper is about

The HPLC method was used to investigate the degradation kinetic characters of sodium lauroyl-α-hydroxyethyl sulfonate(sodium neohouttuynin) at different pH buffer.With comparative regression analysis of linear fi t,the degradation met the second-order kinetics in pH 4.0 -11.0 phosphate buffer.It showed that the degradation rate(K) was influenced significantly by pH.The pH-K curve was bell-like.The degradation rate was fast at pH 7.0 -8.0 and sodium lauroyl-α-hydroxyethyl sulfonate was relatively stable in the solution at pH 4.0 or pH 11.0.Therefore,the degradation was not simply an acid-base catalytic reaction.There might be some speed control steps at particular pH.

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Available abstract

The HPLC method was used to investigate the degradation kinetic characters of sodium lauroyl-α-hydroxyethyl sulfonate(sodium neohouttuynin) at different pH buffer.With comparative regression analysis of linear fi t,the degradation met the second-order kinetics in pH 4.0 -11.0 phosphate buffer.It showed that the degradation rate(K) was influenced significantly by pH.The pH-K curve was bell-like.The degradation rate was fast at pH 7.0 -8.0 and sodium lauroyl-α-hydroxyethyl sulfonate was relatively stable in the solution at pH 4.0 or pH 11.0.Therefore,the degradation was not simply an acid-base catalytic reaction.There might be some speed control steps at particular pH.

Key concepts: Chemistry, Sulfonate, Degradation (telecommunications), Aqueous solution, Kinetics, Base (topology), Sodium, Phosphate buffered saline

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