Relationship between expressions of survivin,PTEN protein and their clinicopathologic significance in primary gallbladder carcinoma

Objective To study the correlations of survivin and PTEN protein expression with histological type, pathological grading and metastasis. Methods Immunohistochemistry was used to investigate the expression of survivin and PTEN protein in 52 cases of gallbladder carcinoma,20 cases of gallbladder adenoma and 20 cases of chronic cholecystis. Results The expression rates of survivin in gallbladder carcinoma, gallbladder adenoma and chronic cholecystis were 67.3%(35/52),30%(6/20) and 0(0/20), respectively. The expression rates of PTEN in gallbladder carcinoma, gallbladder adenoma and chronic cholecystis were 42.3%(22/52),80.0%(6/20) and 100%(20/20), respectively. The differences among groups were significant(P0.05).The high expression of survivin and the low expression of PTEN were positively correlated with the pathological grading, serosa infiltration and metastasis in gallbladder carcinoma(P0.05).The expression of survivin showed a negative correlation with PTEN expression in gallbladder carcinoma(P0.05). Conclusion These data show a correlation between survivin and PTEN expression and potential of invasion and metastasis in gallbladder carcinoma. Survivin and PTEN may be prognostic indicators in gallbladder carcinoma.