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2003•Medical Journal of National Defending Forces in North ChinaRequires access

Expressions of E-cadherin and PTEN gene in carcinoma of gallbladder and their clinical significance

Shang Pei-zhon

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Abstract

Objective To explore the significance of E-cadherin (ED) and PTEN gene expressions in gallbladder carcinoma. Methods Immunohistochemistry was applied to investigate the expressions of ED and PTEN gene in 52 cases of gallbladder carcinoma,20 cases of gallbladder adenoma and 10 cases of chronic cholecystis. Results The positive rates of ED and PTEN were both 42. 3% in carcinoma of gallbladder, which were much lower than those in gallbladder adenoma and chronic cholecystis. ED and PTEN expressions were closely correlated with the pathological grading, serosa infiltration and metastasis of the carcinoma (P 0. 05 ). The expression of ED was strongly associated with the expression of PTEN ( P 0. 05). Conclusions Expressions of ED and PTEN could be helpful in evaluation of the biological behavior and prognosis of gallbladder carcinoma.

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Objective To explore the significance of E-cadherin (ED) and PTEN gene expressions in gallbladder carcinoma. Methods Immunohistochemistry was applied to investigate the expressions of ED and PTEN gene in 52 cases of gallbladder carcinoma,20 cases of gallbladder adenoma and 10 cases of chronic cholecystis. Results The positive rates of ED and PTEN were both 42. 3% in carcinoma of gallbladder, which were much lower than those in gallbladder adenoma and chronic cholecystis. ED and PTEN expressions were closely correlated with the pathological grading, serosa infiltration and metastasis of the carcinoma (P 0. 05 ). The expression of ED was strongly associated with the expression of PTEN ( P 0. 05). Conclusions Expressions of ED and PTEN could be helpful in evaluation of the biological behavior and prognosis of gallbladder carcinoma.

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Available abstract

Objective To explore the significance of E-cadherin (ED) and PTEN gene expressions in gallbladder carcinoma. Methods Immunohistochemistry was applied to investigate the expressions of ED and PTEN gene in 52 cases of gallbladder carcinoma,20 cases of gallbladder adenoma and 10 cases of chronic cholecystis. Results The positive rates of ED and PTEN were both 42. 3% in carcinoma of gallbladder, which were much lower than those in gallbladder adenoma and chronic cholecystis. ED and PTEN expressions were closely correlated with the pathological grading, serosa infiltration and metastasis of the carcinoma (P 0. 05 ). The expression of ED was strongly associated with the expression of PTEN ( P 0. 05). Conclusions Expressions of ED and PTEN could be helpful in evaluation of the biological behavior and prognosis of gallbladder carcinoma.

Key concepts: PTEN, Gallbladder, Grading (engineering), Carcinoma, Medicine, Immunohistochemistry, Pathological, Gallbladder cancer

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Expressions of E-cadherin and PTEN gene in carcinoma of gallbladder and their clinical significance — Research Paper | ScholarLens