Expressions of antioncogene Survivin and Pten in gallbladder carcinoma and correlative analysis

Objective To investigate the expression of Survivin and Pten in gallbladder carcinoma and study their relationship.Methods Expression of Survivin and Pten was detected by immunohistochemical technique in 51 cases of gallbladder carcinoma,13 cases of chronic cholecystitis and 26 cases of normal gallbladder tissue.Results Positive expression rate of Survivin was 80.4% in gallbladder carcinomas(40/51),and which was 0 in 13 cases of cholecystitis and 26 cases of normal gallbladder tissue,while positive expression rate of Pten in gallbladder carcinomas was 29.4%,and which was 1000% in chronic cholecystitis and normal gallbladder tissue,and there were significant difference between two groups(P0.01).Expressions of Survivin and Pten were no correlation with patient age,sex,clinical stage of gallbladder carcinoma and lymph metastasis.There was negative relation between Survivin expression and Pten expression(r=-0.499,P=0.000).Conclusion Pten played an inhibitive roles in proliferation of gallbladder cells,but Survivin did in apoptosis.High expression of Survivin and Low expression of Pten may be correlation with the progression of gallbladder carcinoma.It will be help for diagnosis of gallbladder carcinoma to detect expressions of Survivin and Pten.