Expressions of PTEN,E-cadherin and CD44v6 in esophageal squamous cell carcinoma tissue

Aim:To explore the relationship between the expressions of PTEN,E-cadherin,CD44v6 and the clinical pathologic features of esophageal carcinoma.Methods:Immunohistochemistry SP was used to detect PTEN,E-cadherin and CD44v6 in 39 cases of normal esophageal tissues,23 cases of esophageal atypical hyperplasia tissues,and 52 cases of esophageal squamous cell carcinoma.Results:From the normal esophageal tissues,esophageal atypical hyperplasia to esophageal squamous cell carcinoma tissues,the positive expression rates of PTEN and E-cadherin decreased(χ2=14.322,21.622,P0.001),but that of CD44v6 increased(χ2=19.372,P0.001).The positive expression rates of PTEN and E-cadherin decreased with the decline of differentiation degree(P0.01)and the rise of invasion depth(P0.05).The positive expression rates of PTEN and E-cadherin were lower in carcinoma tissues with lymph node metastasis than those without (χ2=9.871,6.502;P=0.002,0.011).The positive expression rate of CD44v6 increased with the decline of differentiation degree and the rise of invasion depth(P0.05).The positive expression rate of CD44v6 was higher in carcinoma tissues with lymph node metastasis than those without(χ2 adj =4.442,P=0.035).The expressions of PTEN were positively related to E-cadherin(r p =0.601,P0.001),and both the expressions of E-cadherin and PTEN were negatively related to CD44v6(r p =0.587,0.531,P0.001).Conclusion:PTEN,E-cadherin and CD44v6 might participate in the incidence,development,invasion and metastasis of esophageal squamous cell carcinoma.