The curative effect of tiotropium bromide in treating stable chronic obstructive pulmonary disease

Objective To evaluate the effect and safety of tiotropium bromide in treating stable chronic obstructive puhnonary disease(COPD).Methods A randomized clinical trial was conducted in 50 patients(age 40～75 years)with mild and moderate COPD.25 patients in tiotropium group were treated by tiotropium bromide powder(18μg,qd,inhaled)and another 25 patients in controlled group were given no medizine altogether for 13 weeks.The spirometry was conducted at before treatment,2 weeks and 4 weeks after treatment.Results Forced expiratory volum in one second(FEV1),forced vital capacity(FVC),FEV1/FVC,FEV1/Pred% were significantly increased after treatment in the tiotropium groups(P0.05).The major adverse event in the tiotropium group was dry mouth(8%).No cardiac disorder or abnormal electrocardiogram was reported.Conclusion Tiotropium bromide is an effective and safe bronchodilator in the treating mild to moderate stable COPD patients.