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THE APPLICATION OF TIOTROPIUM IN THE SEQUENTIAL THERAPY FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Lin Zengrui

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Abstract

Objective To investigate the efficacy and safety of tiotropium bromide in treating chronic obstructive pulmonary disease(COPD).Methods 60patients was randomly divided into the treatment group(30 cases) and control group(30 cases),the treatment group was treated with tiotropium bromide,and the control group was treated with ipratropium.The spirometry was conducted at 1 month,6 months and 12months after treatment and record the times of acute exacerbations in 12 months.Results Forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/Pred% and times of acute exacerbations were significantly better after treatment in the tiotropium groups(p0.05).The major adverse event was dry mouth(6%);no other bad effect was reported.Conclusion Tiotropium bromide is an effective and safe bronchodilator in the treating moderate COPD patients.

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What this paper is about

Objective To investigate the efficacy and safety of tiotropium bromide in treating chronic obstructive pulmonary disease(COPD).Methods 60patients was randomly divided into the treatment group(30 cases) and control group(30 cases),the treatment group was treated with tiotropium bromide,and the control group was treated with ipratropium.The spirometry was conducted at 1 month,6 months and 12months after treatment and record the times of acute exacerbations in 12 months.Results Forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/Pred% and times of acute exacerbations were significantly better after treatment in the tiotropium groups(p0.05).The major adverse event was dry mouth(6%);no other bad effect was reported.Conclusion Tiotropium bromide is an effective and safe bronchodilator in the treating moderate COPD patients.

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Available abstract

Objective To investigate the efficacy and safety of tiotropium bromide in treating chronic obstructive pulmonary disease(COPD).Methods 60patients was randomly divided into the treatment group(30 cases) and control group(30 cases),the treatment group was treated with tiotropium bromide,and the control group was treated with ipratropium.The spirometry was conducted at 1 month,6 months and 12months after treatment and record the times of acute exacerbations in 12 months.Results Forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/Pred% and times of acute exacerbations were significantly better after treatment in the tiotropium groups(p0.05).The major adverse event was dry mouth(6%);no other bad effect was reported.Conclusion Tiotropium bromide is an effective and safe bronchodilator in the treating moderate COPD patients.

Key concepts: Tiotropium bromide, Medicine, Ipratropium bromide, COPD, Spirometry, Pulmonary disease, Vital capacity, Bronchodilator

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