Antitumor Biological Activity of Polyprenyl Phosphate from Leaves of Ginkgo biloba L.in vivo and vitro

The researches of pharmacology of polyprenyl phosphate(PPH) from Ginkgo biloba L.on antitumor in vitro and in vivo were carried out.After extracting,separating and purifying the mixs of polyprenols(C_(75)-C_(110)) from leaves of G.biloba L.,polyprenyl monophosphates were synthesized from polyprenols with POCl_3 and triethanylamide.In contrast to 5-Fu,the antitumor(activities) were studied in vitro with SGC-7901,LoVo and Hela,and in vivo with mice transplanted tumors of Heps,S_(180) and EC Heps,S_(180) and EC.The pharmacologic experiments were done by various doses of PPH.Results show that PPH have the inhibition of(60%)-(80%) against SGC-7901,LoVo and Hela in vitro at high concentration of(0.400g/L) after(72h),and have the(inhibition) of(50%)-(65%) against transplanted Heps,S_(180) and EC.This shows that PPH from leaves of G.biloba L.has distinct antitumor biological activity.